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Testing Status of Lauric acid diethanolamine condensate 10744-T

 

CASRN: 120-40-1

Formula: C16-H33-N-O3

Synonyms/Common Names

  • Dodecanamide, N,N-bis(2-hydroxyethyl)-(8CI) (9CI)

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C55323B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 50, 100, 200, OR 400 MG/KG; 20/SEX/GROUP M: 0, 50, 100, 200, 400, OR 800 MG/KG; 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C55323B)  Completed 
    • TR-480 (NIH Number: 99-3970)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 50, OR 100 MG/KG M: 0, 100, OR 200 MG/KG (50/SEX/SPECIES/GROUP).

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Topical Application)  (S0611)  Completed 
    • Citation: Mathews JM, deCosta K, Thomas BF. Lauramide diethanolamine absorption, metabolism, and disposition in rats and mice after oral, intravenous, and dermal administration. Drug Metab Dispos. 1996 Jul;24(7):702-10.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 1000 mg/kg. 25 and 400 mg/kg. 25 mg/kg. 50 mg/kg. 50, 100, 200, and 800 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (836554)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A82445)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Mouse Lymphoma  (920902)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (854154)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative