Testing Status of p-Anisidine hydrochloride 10775-W

CASRN: 20265-97-8

Related: TRANSGENIC MODEL EVALUATION (P-ANISIDINE HCL)

Formula: C7-H9-N-O.Cl-H

Synonyms/Common Names

• 4-Methoxybenzenamine hydrochloride

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03758)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03758)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0, 0.1, 3.0 %/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03758)  Completed 
  • TR-116 (NIH Number: 78-1371)  (Peer Review Approval 04/26/1978A )
    Bioassay of p-Anisidine Hydrochloride for Possible Carcinogenicity (CASRN 20265-97-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Equivocal 
    • Female Rats Negative 
    • Male Mice Negative 
    • Female Mice Negative 
  • Dose: R: 0, .3, .6, M: 0, .5, 1.0 %/55 PER GROUP.

Genetic Toxicology

• Mouse Lymphoma  (802685)  Completed 
  • Mice
  •  Positive 
• Salmonella  (N-9339)  Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248