Testing Status of Coconut oil acid diethanolamine condensate 10802-J

CASRN: 68603-42-9

Formula: Rc N(CH2CH2OH)2

Synonyms/Common Names

• Amides, coco, N,N-bis(hydroxyethyl)
• Coconut diethanolamide
• Coconut oil acid diethanolamine (con 2/1)
• Coconut oil acid/diethanolamine condensate

Short-Term Toxicity

• 13 weeks (Topical Application)  (C55312B)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 25, 50, 100, 200, or 400 mg/kg; 20/sex/group M: 0, 50, 100, 200, 400, or 800 mg/kg; 10/sex/group.

Long-Term Carcinogenicity

• 2 years (Topical Application)  (C55312B)  Completed 
  • TR-479 (NIH Number: 01-3969)  (Peer Review Approval 12/10/1997A )
    Toxicology and Carcinogenesis Studies of Coconut Oil Acid Diethanolamine Condensate (CASRN 68603-42-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats No Evidence 
    • Female Rats Equivocal Evidence 
    • Male Mice Clear Evidence 
    • Female Mice Clear Evidence 
  • Dose: R: 0, 50, or 100 mg/kg M: 0, 100, or 200 mg/kg (50 sex/species/group).

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (898613)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberrations Negative 
• Micronucleus  (A44271)  Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Positive 
• Mouse Lymphoma  (876640)  Completed 
  • Mice
  •  Negative 
• Salmonella  (104376)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative