Testing Status of Chloramben 10823-E

CASRN: 133-90-4

Formula: C7-H5-Cl2-N-O2

Synonyms/Common Names

• Amiben
• 3-Amino-2,5-dichlorobenzoic acid

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00055)  Completed 
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00055)  Completed 
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0, 2000, 32000, M: 0, 1250, 30000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00055)  Completed 
  • TR-025 (NIH Number: 77-825)  (Peer Review Approval 09/26/1977A )
    Bioassay of Chloramben for Possible Carcinogenicity (CASRN 133-90-4)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Negative 
    • Female Rats Negative 
    • Male Mice Equivocal 
    • Female Mice Positive 
  • Dose: 0, 10000, 20000 PPM/50 PER GROUP.

Genetic Toxicology

• Drosophila  (035040)  Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
• In Vitro Cytogenetics (CA/SCE)  (783500)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Salmonella  (537889)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive