Testing Status of Dieldrin 10834-R
CASRN: 60-57-1
Formula: C12-H8-Cl6-O
Synonyms/Common Names
- 3,4,5,6,9,9-Hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C00124A)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- 14-Day (Dosed-Feed)
(C00124B)
Completed
- Rats: F344/N
- 13-Week (Dosed-Feed)
(C00124A)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0, 40, 320, M: 0, 2.5, 40 PPM/10 PER GROUP.
- 13-Week (Dosed-Feed)
(C00124B)
Completed
- Rats: F344/N
- Dose: 0, 25, 300 PPM/30 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C00124A)
Completed
- TR-021 (NIH Number: 78-821)
(Peer Review Approval 09/26/1977A )
Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Equivocal
- Female Mice Negative
- Dose: R: 0, 30, 60, M: 0, 2.5, 5 PPM/50 PER GROUP.
- TR-021 (NIH Number: 78-821)
(Peer Review Approval 09/26/1977A )
- 109 weeks (Dosed-Feed)
(C00124B)
Completed
- TR-022 (NIH Number: 78-822)
(Peer Review Approval 11/28/1977A )
Bioassay of Dieldrin for Possible Carcinogenicity (CASRN 60-57-1) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Dose: 0, 2, 10, 50 PPM/48 PER GROUP.
- TR-022 (NIH Number: 78-822)
(Peer Review Approval 11/28/1977A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(268228)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Mouse Lymphoma
(145014)
Completed
- Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
- Mice
- Positive
- Salmonella
(210083)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative