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Testing Status of Chloropicrin 10848-P

 

CASRN: 76-06-2

Formula: C-Cl3-N-O2

Synonyms/Common Names

  • Trichloronitromethane

Short-Term Toxicity

  • 14-Day (Gavage)  (C00533)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C00533)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 16, 100, M: 0, 10, 63 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C00533)  Completed 
    • TR-065 (NIH Number: 78-1315)  (Peer Review Approval 01/18/1978A )
      Bioassay of Chloropicrin for Possible Carcinogenicity (CASRN 76-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate 
      • Female Rats Inadequate 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: FR: 0, 20, 22 (AVG), MR: 0, 25, 26 (AVG), M: 0, 33, 36 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • Drosophila  (149367)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (405202)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (643495)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (678673)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive