Testing Status of Nitromethane 10851-V

CASRN: 75-52-5

Related: FISH PROJECT (NITROMETHANE)

Formula: C-H3-N-O2

Synonyms/Common Names

• Nitrocarbol

Short-Term Toxicity

• 2 weeks (Inhalation)  (C61927)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 94, 188, 375, 750, OR 1500 PPM (5/S/S).
• 13 weeks (Inhalation)  (C61927)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 94, 188, 375, 750, OR 1500 PPM; RATS 20/GROUP, MICE 10/GROUP.

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C61927)  Completed 
  • TR-461 (NIH Number: 97-3377)  (Peer Review Approval 12/05/1995A )
    Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats No Evidence 
    • Female Rats Clear Evidence 
    • Male Mice Clear Evidence 
    • Female Mice Clear Evidence 
  • Dose: R: 0, 94, 188, OR 375 PPM; 50/GROUP M: 0, 188, 375, OR 750 PPM; 50/GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (703142)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberrations Negative 
• Micronucleus  (A55749)  Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (860172)  Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative