Dimethylnitrosamine (62-75-9)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7021029
Publications
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex-linked recessive lethal mutations and reciprocal translocations in three laboratories Environ. Mutagen. Vol. 6 (1984) 189-202
Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling
Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS
Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448
Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448
Study Data
Toxicity and Carcinogenicity Studies
150-Day Evaluation of the Toxicity (C20540D) of N-Nitrosodimethylamine (TGMX Rat Liver Evaluation) (62-75-9) in F344/NTac Rats Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 118997
Summary Data
- G06 - Ames Summary Data (104 KB)
Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 182581
Summary Data
- G06 - Ames Summary Data (107 KB)
Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 320614
Summary Data
- G06 - Ames Summary Data (108 KB)
Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 810034
Summary Data
- G06 - Ames Summary Data (177 KB)
Other NTP Studies
2-Week Immunotoxicity Evaluation (IMM83001) of n-Nitrosodimethylamine (62-75-9)) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection
B6CF1 Mice Individual and Summary Data
- Absolute Leukocyte Differentials (10 kB)
- Delayed Hypersensitivity Response (DHR) to Keyhole Limpet Hemocyanin (KLH) (8 kB)
- Hematology (15 kB)
- Host Resistance to B16F10 Melanoma Tumors (5 kB)
- Infection with Plasmodium Berghei (3 kB)
- Lymphocyte Proliferation (26 kB)
- Mixed Leukocyte Response (18 kB)
- Organ Weights (17 kB)
- Resistance to Infection with Listeria Monocytogenes (27 kB)
- Resistance to Infection with Streptococcus Pneumoniae (27 kB)
- Serum Complement (CH50) (units/ml) (13 kB)
- T-Dependent AB Response Day 4 (19 kB)
- T-Dependent AB Response Day 5 (19 kB)
- T-Dependent AB Response Day 6 (17 kB)