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Dimethylnitrosamine (62-75-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7021029


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Dimethylnitrosamine (62-75-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Dimethylnitrosamine (62-75-9).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Dimethylnitrosamine (62-75-9).
Bacterial Mutagenicity
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  • Positive
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  • Positive
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  • Positive
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  • Positive

Citation Information


NTP. Dimethylnitrosamine (62-75-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex-linked recessive lethal mutations and reciprocal translocations in three laboratories Environ. Mutagen. Vol. 6 (1984) 189-202
Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS

Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448

Study Data


Genetic Toxicology Studies


Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 118997
Summary Data
Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 182581
Summary Data
Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 320614
Summary Data
Genetic Toxicity Evaluation of N-Nitrosodimethylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 810034
Summary Data

Other NTP Studies


2-Week Immunotoxicity Evaluation (IMM83001) of n-Nitrosodimethylamine (62-75-9)) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection