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Testing Status of n-Butyl acrylate 10859-C

 

CASRN: 141-32-2

Formula: C7-H12-O2

Synonyms/Common Names

  • Acrylic acid, butyl ester
  • Butyl acrylate
  • 2-Propenoic acid, butyl ester

Special Studies

  • Absorption Disposition Metabolism Elimination (Intraperitoneal Injection)  (S0731)  Completed 
    • Citation: Sanders JM, Burka LT, Matthews HB. Metabolism and disposition of n-butyl acrylate in male Fischer rats. Drug Metab Dispos. 1988 May-Jun;16(3):429-34.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism (Dosed-Feed)  (S0123)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: NVITRO STUDIES.

Genetic Toxicology

  • Drosophila  (038839)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (679128)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (398442)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (T0103)  Completed 
    • Female Mice: Swiss
    • Dose: 0, 0.1, 1.0, 1.5, 2.0, 2.5, 3.0 MG/KG/DAY.
  • 4 days, 8 days Immunotoxicity (Topical Application)  (IMM95005)  Completed 
    • Female Mice: B6C3F1
    • Dose: 10, 20, AND 30% IN ACETONE (99.8%) FOR SENSITIZATION AND 30% FOR CHALLENGE; 0.25% DNFB AS POSITIVE CONTROL AND 0.5% FOR CHALLENGE.