Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of C.I. Direct Blue 6 10883-C

 

CASRN: 2602-46-2

Formula: C32-H24-N6-O14-S4.4Na

Synonyms/Common Names

  • 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt
  • Blue 6, C.I. Direct

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C54579A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 190, 375, 750, 1500, OR 3000 PPM M: 0, 750, 1500, 3000, 6000, OR 12500 PPM; 10 PER GROUP.
  • 13 weeks (Dosed-Feed)  (C54579A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 750, 1500, 2000, 6000, OR 12500 PPM M: 0, 190, 375, 750, 1500, OR 3000 PPM.
  • 13-Week (Dosed-Water)  (C54579B)  Completed 
    • Rats: F344/N
    • Dose: 0, .019, .3 %/10 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (160428)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (831122)  Completed 
    • Mice
    •  Positive 
  • Salmonella Reduction  (461569)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive 
  • Salmonella  (241000)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (849964)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Subcutaneous Injection)  (T0123)  Completed 
    • Female Mice: Swiss
    • Dose: 0, 50, 75, 100, 200 MG/KG/DAY.