4-Chloro-o-phenylenediamine (95-83-0)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020283
Study Results
Chronic Bioassay Level of Evidence
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Mice | |
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Genetic Toxicology
Rodent Cytogenetics | |
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CA | SCE |
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Micronucleus - Mice |
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Mammalian Cell Cytogenetics | |
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CA | SCE |
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Bacterial Mutagenicity |
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Publications
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
Study Data
Toxicity and Carcinogenicity Studies
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Female B6C3F1 Mice Exposed via Dosed Feed
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 4-Chloro-o-phenylenediamine (95-83-0) in Micronucleus Study A99443 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 4-Chloro-o-phenylenediamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 200662
Summary Data
- G06 - Ames Summary Data (139 KB)
Other NTP Studies
2-Week Immunotoxicity Evaluation (IMM86001) of Toluenes (2-4-Diaminotoluene, p-Nitrotoluene, 4-Chloro-o-Phenylenediamine) (TOLUENES) in Female B6C3F1 Mice Exposed via Gavage
B6CF1 Mice Individual and Summary Data
- Hematology (9 kB)
- Host Resistance to B16F10 Melanoma Tumors (6 kB)
- Infection With Plasmodium Yoelii (5 kB)
- Organ Weights (20 kB)
- PYB6 Tumor Incidence (45 kB)
- Resistance to Infection with Listeria Monocytogenes (30 kB)
- Resistance to Infection with Streptococcus Pneumoniae (32 kB)
- T-Dependent AB Response Day 4 (12 kB)