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Pyrimethamine (58-14-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID9021217

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Inadequate Study, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Pyrimethamine (58-14-0).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Pyrimethamine (58-14-0).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Pyrimethamine (58-14-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-077 Bioassay of Pyrimethamine for Possible Carcinogenicity (CASRN 58-14-0)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Pyrimethamine (58-14-0) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Pyrimethamine (58-14-0) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Pyrimethamine (58-14-0) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Pyrimethamine (58-14-0) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Pyrimethamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 368591
Summary Data

Other NTP Studies

28-Day Immunotoxicity Evaluation (IMM96013) of AZT + Pyrimethamine Combination (Aids) (AZT/PYRIMETH) in B6C3F1 Mice via Gavage
B6CF1 Mice Individual and Summary Data

NTP Data Collections