Testing Status of 1,1,2,2-Tetrachloroethane 10915-J
CASRN: 79-34-5
Related: HALOGENATED ETHANES CS (1,1,2,2-TETRACHLOROETHANE)
Formula: C2-H2-Cl4
Synonyms/Common Names
- Acetylene tetrachloride
- Acetylenetetrachloride
- TCE
Short-Term Toxicity
- 14-Day (Gavage)
(C03554A)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- 2 weeks (Microencapsulation in Feed)
(C03554B)
Completed
- TOX-49 (NIH Number: 04-4414)
Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 3325, 6650, 13300, 26600, OR 53200 PPM (5/SEX/SPECIES/GROUP).
- TOX-49 (NIH Number: 04-4414)
- 2 weeks (Gavage)
(C03554C)
Completed
- TOX-49 (NIH Number: 04-4414)
Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 135, 270, OR 540 MG/KG M: 0, 337.5, 675, OR 1350 MG/KG (50/SEX/SPECIES).
- TOX-49 (NIH Number: 04-4414)
- 13-Week (Gavage)
(C03554A)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0, 56, 562, M: 0, 32, 136 MG/KG/10 PER GROUP.
- 14 weeks (Microencapsulation in Feed)
(C03554E)
Completed
- TOX-49 (NIH Number: 04-4414)
(Tox Peer Review 05/23/2002A )
Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: UNTREATED CONTROLS; VEHICLE CONTROLS; 268, 589, 1180, 2300 OR 4600 PPM (RATS) OR 589, 1120, 2300, 4550 OR 9100 PPM (MICE) 10/SEX/SPECIES/GROUP..
- TOX-49 (NIH Number: 04-4414)
(Tox Peer Review 05/23/2002A )
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C03554A)
Completed
- TR-027 (NIH Number: 78-827)
(Peer Review Approval 09/26/1977A )
Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CASRN 79-34-5) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal
- Female Rats Negative
- Male Mice Positive
- Female Mice Positive
- Dose: FR: 0, 43, 76 (AVG), MR: 0, 62, 108 (AVG), M: 0, 142, 284 (AVG) MG/KG/50 PER GROUP.
- TR-027 (NIH Number: 78-827)
(Peer Review Approval 09/26/1977A )
Genetic Toxicology
- Drosophila
(959130)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(838914)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Micronucleus
(A72450)
Completed
- Mice: B6C3F1
- Male Positive
- Female Positive
- Micronucleus
(B72450)
Completed
- Mice: B6C3F1
- Male Equivocal
- Female Positive
- Mouse Lymphoma
(990809)
Completed
- Mice
- Negative
- Salmonella
(547949)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
- Salmonella
(866388)
Completed
- Negative
Organ Systems Toxicity
- Teratology Pilot Studies (Dosed-Feed)
(TRP91023)
Completed
- Female Mice: Swiss CD-1
- Dose: 0, 4, 7.5, 10.%.
- 6 to 16 GD Teratology Pilot Studies (Dosed-Feed)
(TRP91028)
Completed
- Female Mice: Swiss CD-1
- Dose: 0, .0125, .05, .1, .2, OR .3 %.
- 6 to 16 GD Teratology Pilot Studies (Dosed-Feed)
(TRP91029)
Completed
- Female Rats: Sprague Dawley
- Dose: 0, 0.045, 0.135, 0.270, 0.405, OR 0.540%.
- 6 to 15 GD Teratology Pilot Studies (Dosed-Feed)
(TRP91069)
Completed
- Female Mice: Swiss CD-1
- Dose: 0, .5, 1, 1.5, 2, OR 3%.
- Teratology Pilot Studies (Gavage)
(TRP92039)
Completed
- Rabbits: New Zealand White
- Dose: 0, 10, 50, 100, 150, 200 MG/KG.
- Teratology Pilot Studies (Gavage)
(TRP92064)
Completed
- Rats
- Dose: 0, 100, 150, 200, 250 MG/KG.