Testing Status of Pyrazinamide 10916-N

CASRN: 98-96-4

Formula: C5-H5-N3-O

Synonyms/Common Names

• Pyrazinamide (AIDS)
• Pyrazinecarboxamide

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01785)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01785)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: MR&MM: 0, 1000, 50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01785)  Completed 
  • TR-048 (NIH Number: 78-848)  (Peer Review Approval 01/18/1978A )
    Bioassay of Pyrazinamide for Possible Carcinogenicity (CASRN 98-96-4)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Negative 
    • Female Rats Negative 
    • Male Mice Negative 
    • Female Mice Inadequate Study 
  • Dose: 0, 5000, 10000 PPM/35 PER GROUP.

Genetic Toxicology

• Salmonella  (511918)  Completed 
  • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
  •  Negative 

Organ Systems Toxicity

• 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93151)  Completed 
  • Citation: Reproductive/Developmental/General Toxicity Studies of Pyrazinamide in Swiss Mice
  • NIH Number: 97-3938
    Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of Pyrazinamide (CASRN 98-96-4) Administered by Gavage to Swiss (CD-1®) Mice
  • Male and Female Mice: Swiss CD-1
  • Dose: 0, 400, 800, or 1, 200 mg/kg.