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Testing Status of Prednisone 10936-E

 

CASRN: 53-03-2

Formula: C21-H26-O5

Synonyms/Common Names

  • Deltacortisone
  • 17,21-Dihydroxy-pregna-1,4-diene-3,11,20-trione (9CI)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04897)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04897)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04897)  Completed 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: R: 0, 11, 22, 45, M: 0, 6, 12, 25 MG/KG/25 PER GROUP.

Genetic Toxicology

  • Salmonella  (217172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (240172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive