Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Diethylene glycol 10993-P


CASRN: 111-46-6

Formula: C4-H10-O3

Synonyms/Common Names

  • 2,2'-Oxydiethanol

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Dosed-Water; Intravenous; Gavage)  (S0219)  Completed 
    • Citation: Mathews JM, Parker MK, Matthews HB. Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos. 1991 Nov-Dec;19(6):1066-70.Pubmed Abstract
    • Male Rats: F344/N; Female Dogs: Beagles
    • Dose: RATS: IV 50 MG/KG, ORAL 0.3, 1.0 & 3.0%, GAV 50 & 5000 MK/KG; DOGS GAV 500 MG/KG..

Genetic Toxicology

  • Salmonella  (248390)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB83086)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .35, 1.75, 3.5%; N/A; N/A.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER89001)  Completed 
    • Female Mice: Swiss CD-1
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 1250, 5000, 10000 MG/KG/DAY.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0075A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 11, 180 MG(10ML UNDILUTED)/KG BODY WEIGHT.