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Testing Status of Di(n-hexyl)phthalate 10996-C

 

CASRN: 84-75-3

Formula: C20-H30-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, dihexyl ester

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (K10996)  Completed 
    • Male Rats: F344/N
    • Dose: 30 mg/kg.
  • Absorption Disposition Metabolism Elimination (Dosed-Water)  (S0378)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Salmonella  (177536)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (699952)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84093)  Completed 
    • Citation: Lamb JC 4th, Chapin RE, Teague J, Lawton AD, Reel JR. Reproductive effects of four phthalic acid esters in the mouse. Toxicol Appl Pharmacol. 1987 Apr;88(2):255-69. doi: https://doi.org/10.1016/0041-008x(87)90011-1.
    • Citation: National Toxicology Program (NTP). 1985. Di-n-hexyl phthalate (CASRN 84-75-3): Reproduction and fertility assessment in CD-1 mice when administered in the feed. Research Triangle Park, NC: National Toxicology Program. RACB Report 84093. https://ntp.niehs.nih.gov/go/racb84093abs
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, 0.3, 0.6, 1.2%; 0, 1.2%; 0, .3, .6, 1.2%.
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0036A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 9900 (UNDILUTED) MG/KG BODY WT.
  • Utero-Lactational (Gavage)  (R10996)  Completed 
    • Mice: Swiss