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Testing Status of Dimethyl phthalate 11001-Y

 

CASRN: 131-11-3

Formula: C10-H10-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, dimethyl ester

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0043)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (970550)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A47213)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A65972)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (856145)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0098A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 3500 MG/KG BODY WT..
  • 6 to 13 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0098B)  Completed 
    • Female Mice: Swiss
    • Dose: 5000 MG/KG/DY.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER88066)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 0.25, 1.0, 5.0%.
  • Utero-Lactational (Dosed-Water)  (R11001)  Completed 
    • Mice: B6C3F1