Testing Status of Methyl isocyanate 11019-N
CASRN: 624-83-9
Formula: C2-H3-N-O
Synonyms/Common Names
- Isocyanatomethane (9CI)
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C62146)
Completed
- Citation: Bucher JR, Uraih LC, Hildebrandt PK, Sauer RM and Seely JC. Carcinogenicity and Pulmonary Pathology Associated with a Single 2-Hour Inhalation Exposure of Laboratory Rodents to Methyl Isocyanate. J. Nat. Cancer Inst 81:1586-1587 (1989).
- Rats: Not Available; Mice: Not Available
Genetic Toxicology
- Drosophila
(736474)
Completed
- Citation: Mason, J., Zeiger, E., Haworth, S., Ivett, J., and Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosophila, and cultured Chinese hamster ovary cells. Environ. Mutagen. Vol. 9 (1987) 19-28
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(933693)
Completed
- Citation: Mason, J., Zeiger, E., Haworth, S., Ivett, J., and Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosophila, and cultured Chinese hamster ovary cells. Environ. Mutagen. Vol. 9 (1987) 19-28
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(A97304)
Completed
- Citation: Tice, R.R., Luke, C.A., and Shelby, M.D. Methyl isocyanate: An evalution of in vivo cytogenetic activity. Environ. Mutagen. Vol. 9 (1987) 37-58
- Mice: B6C3F1
- Male Negative
- Female Negative
- Mouse Lymphoma
(752783)
Completed
- Citation: Caspary, W., and Myhr, B. Mutagenicity of MIC and its reaction products to cultured mammalian cells. Mutation Res. Vol. 174 (1986) 285-293
- Mice
- Positive
- Salmonella
(290825)
Completed
- Citation: Mason, J.M., Zeiger, E., Haworth, S., Ivette, J., Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosphila, and cultured Chinese hamster ovary cells Environ. Mutagen. Vol. 9 (1987) 19-28
- Negative
- Salmonella
(327434)
Completed
- Citation: Mason, J.M., Zeiger, E., Haworth, S., Ivette, J., Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosphila, and cultured Chinese hamster ovary cells Environ. Mutagen. Vol. 9 (1987) 19-28
- Negative
- Sister Chromatid Exchanges
(A97304)
Completed
- Citation: Tice, R.R., Luke, C.A., and Shelby, M.D. Methyl isocyanate: An evalution of in vivo cytogenetic activity. Environ. Mutagen. Vol. 9 (1987) 37-58
- Mice