Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of p-Nitrobenzoic acid 11024-C

 

CASRN: 62-23-7

Formula: C7-H5-N-O4

Synonyms/Common Names

  • Benzoic acid, 4-nitro- (9CI)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C61778)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C61778)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .062, 1.0, M: 0, .125, 2.0 %.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C61778B)  Completed 
    • TR-442 (NIH Number: 95-3358)  (Peer Review Approval 06/22/1993A )
      Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 1250, 2500, OR 5000 PPM /60 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (195725)  Completed 
    • Citation: Zeiger, E., Shelby, M., Ivett J., and McFee, A. Mutagenicity testing of 5-(4-nitrophenyl)-2, 4-pentadien-1-al ("Spy Dust") and its metabolites in vitro and in vivo. Environ. Mutagen. Vol. 9 (1987) 269-280
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A44876)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (699655)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB90065)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .25, .50, 1.0, 2.0, 3.0; 0, .35, .75, 1.5%; 0, .75%; 0, .35, .75, 1.5%.