Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 4,4-Thiobis(6-tert-butyl-m-cresol) 11035-N

 

CASRN: 96-69-5

Formula: C22-H30-O2-S

Synonyms/Common Names

  • Santonox
  • TBBC
  • 4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C61610A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C61610A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 250, 5000, M: 0, 500, 10000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C61610B)  Completed 
    • TR-435 (NIH Number: 95-3166)  (Peer Review Approval 06/22/1993A )
      Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6-t-butyl-m-cresol) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, .05, .1, .25, M: 0, .025, .05, .1 %.

Special Studies

  • Absorption Distribution Metabolism Excretion (Intravenous)  (S0674)  Completed 
    • Citation: Borghoff SJ, Stefanski SA, Birnbaum LS. The effect of age on the glucuronidation and toxicity of 4,4'-thiobis(6-t-butyl-m-cresol). Toxicol Appl Pharmacol. 1988 Mar 15;92(3):453-66.Pubmed Abstract
    • Rats: F344/N
  • Absorption Distribution Metabolism Excretion (Topical Application)  (S0675)  Completed 
    • Citation: Birnbaum LS, Heaney SM. Dermal absorption of the antioxidant 4,4'-thiobis(6-tert-butyl-m-cresol) in Sencar mice and Fischer rats. Toxicol Lett. 1987 Jun;37(1):13-9.Pubmed Abstract
    • Rats: F344/N; Mice: Sencar
  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0677)  Completed 
    • Citation: Birnbaum LS, Eastin WC Jr, Johnson L, Matthews HB. Disposition of 4,4'-thiobis(6-t-butyl-m-cresol) in rats. Drug Metab Dispos. 1983 Nov-Dec;11(6):537-43.Pubmed Abstract
    • Rats: F344/N
  • Metabolism (Intravenous)  (S0676)  Completed 
    • Citation: Smith RW, Matthews HB, Parker CE, Hass JR. Identification of the major metabolite of 4,4'-thio-bis-(6-t-butyl-m-cresol). Biomed Mass Spectrom. 1985 May;12(5):208-14.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (395386)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (755282)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM95009)  Completed 
    • Female Mice: B6C3F1
    • Mice Female  NO OVERT TOXICITY
    • NO OVERT TOXICITY
    • Dose: 0, 10, 100, OR 200 MG/KG.
  • Neurotoxicology Assessment (Dosed-Feed)  (NTA94011)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats: F344/N
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0043)  Completed 
    • Female Mice: Swiss