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Testing Status of Triphenyl Phosphate 11042-J

 

CASRN: 115-86-6

Formula: C18-H15-O4-P

Synonyms/Common Names

  • Flame Retardant 1
  • Phosphoric acid, triphenyl ester (9CI)
  • TPHP
  • TPP

Planned Carcinogenicity/Toxicity

  • 1 day (Gavage) Selected (C11042D)  
    • Series Dose Escalation Cardiovascular Functional Assessment Study
    • Rats: Hsd:Sprague Dawley SD
    • Dose: Dose escalation, Single dose + recovery per dose level 0, 1, 10, 30, 100, 250 mg/kg.

Short-Term Toxicity

  • 5 days (Gavage)  (C11042)  Completed 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Rats: Harlan Sprague-Dawley
    • Dose:  0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.
  • 14 days (Gavage)  (C11042C)  On Test 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 1, 10, 30, 100, 250 mg/kg.
  • 2 weeks (Dosed-Feed)  (C20720)  Data in Review 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Mice: B6C3F1/N
    • Dose: 0, 1875, 3750, 7500, 15000, or 30000 ppm; 5/sex.
  • 3 months Subchronic (Dosed-Feed)  (C11042B)  On Test 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 30, 100, 300, 1000, 3000 ppm.

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG11042)  Completed 
    • Citation: Witchey SK, Sutherland V, Collins B, Roberts G, Shockley KR, Vallant M, Krause J, Cunny H, Waidyanatha S, Mylchreest E, Sparrow B, Moyer R, Behl M. Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats. Toxicol Sci. 2022 Dec 23:kfac135. doi: https://doi.org/10.1093/toxsci/kfac135.
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 3000, 10000, 15000, or 30000 ppm.

Special Studies

  • C. elegans  (W11042)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, .04, 0.63, .1, .16, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40uMRepro: 0, 0.1, 0.16, 0.25, 0.4, 0.63, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Genetic Toxicology

  • 90 days Micronucleus (Dosed-Feed) Selected (G11042)  
    • Rats: Hsd:Sprague Dawley SD
  • Salmonella  (888679)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 8 days and 15 days Immunotoxicity (Topical Application & Intraductal Injection)  (IMM92060)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.1, 0.3, 1, 3, 10, OR 30% IRRITANCY ASSAY AND 0, 1.0, 3.0, 10, OR CHALLENGE 30% HYPERSENSITIVITY ASSAY.

Toxicogenomics

  • Microarray Analysis (Gavage)  (T11042)  Completed 
    • Rats: Harlan Sprague-Dawley