Testing Status of Trimethylsilyldiazomethane (TMSD) 11049
- Diazomethyltrimethyl silane
- 1 or 5 days (Inhalation)
- Toxicity studies of TMSD
Toxicity Studies of Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered by Nose-only Inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
- Rats: Harlan Sprague-Dawley; Mice: B6C3F1
- Dose: 1 Day: male rats and mice (N = 16/ exp. group) exposed to hexane, air or 10 ppm TMSD; N = 8 necropsied day after exposure and N = 8 necropsied 9 days after exposure. 5 Day: male rats and mice (N = 16/ exp. group) exposed to hexane, air, or 0.2, 1, 5, or 10 ppm TMSD; N = 8 necropsied day after final exposure, N = 8 necropsied 5 days after final exposure.