Sulfolane (126-33-0)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3027037
Publications
Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage
K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1
1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.
DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0000-0000-0
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
Genetox data was added on August 7, 2020
1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.
DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0000-0000-0
Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.
Genetox data was added on August 7, 2020
Disposition and metabolism of sulfolane in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans
Waidyanatha S, Black S, Blystone C, Patel P,Watson S, Snyder R, Fennell T
DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0014-0000-5
DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0014-0000-5
Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison
Suramya Waidyanatha, Sherry R. Black, Timothy R. Fennell, Scott L. Watson, Purvi R.Patel, Stephen D. Cooper, James Blake, Veronica Godfrey Robinson, Reshan A.Fernando, Chad R. Blystone
DOI: https://doi.org/10.1016/j.taap.2019.114690
Immunotoxicity Studies of Sulfolane Following Developmental Exposure in Hsd:Sprague Dawley SD Rats and Adult Exposure in B6C3F1/N Mice.
K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1
1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.
Note: The PA46 was updated on September 14, 2021 for updates to stats for calculation of % animals with a finding.
Note: M09 was updated for number of spleen cells on September 1, 2021. The new tables contain a correction to a typographical error in the units for the Ig concentrations.
Note: M07 was updated for number of spleen cells on July 22, 2021. The I07 was updated on August 12, 2021 to reflect updated footnotes. The I04G was also updated on August 22, 2021 to reflect updated statistical analysis.
DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0016-0000-7
1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.
Note: The PA46 was updated on September 14, 2021 for updates to stats for calculation of % animals with a finding.
Note: M09 was updated for number of spleen cells on September 1, 2021. The new tables contain a correction to a typographical error in the units for the Ig concentrations.
Note: M07 was updated for number of spleen cells on July 22, 2021. The I07 was updated on August 12, 2021 to reflect updated footnotes. The I04G was also updated on August 22, 2021 to reflect updated statistical analysis.
DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0016-0000-7
Study Data
Toxicity and Carcinogenicity Studies
4-Week Evaluation of the Toxicity (C11054) of Sulfolane (126-33-0) in Harlan Sprague Dawley Rats Exposed via Gavage
Study Tables
- I01 - Animal Removal Summary (41 kB)
- I02 - Animal Removals (557 kB)
- I03 - Growth Curve (687 kB)
- I04 - Mean Body Weights and Survival (197 kB)
- I04G - Mean Body Weight Gain (76 kB)
- I05 - Clinical Observations Summary (80 kB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (431 kB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (412 kB)
- PA06 - Organ Weights Summary (161 kB)
- PA10 - Statistical Analysis of Non-Neoplastic Lesions (354 kB)
- PA14 Individual Animal Pathology Data (3 mB)
- PA18 - Non-Neoplastic Lesion Summary with Severity Grade (432 kB)
- PA41 - Clinical Chemistry Summary (238 kB)
- PA43 - Hematology Summary (325 kB)
- PA46 - Summary of Gross Pathology (464 kB)
- PA48 - Summary of Tissue Concentration (52 kB)
- Rectal Temperature Summary (37 kB)
Individual Animal Data
- Individual Animal Body Weight Data (84 kB)
- Individual Animal Clinical Chemistry Data (22 kB)
- Individual Animal Clinical Observations Data (71 kB)
- Individual Animal Gross Pathology Data (330 kB)
- Individual Animal Hematology Data (29 kB)
- Individual Animal Histo Pathology Data (224 kB)
- Individual Animal Organ Weight Data (31 kB)
- Individual Animal Removal Reasons Data (14 kB)
- Individual Animal Temperature Data (16 kB)
- Individual Animal Tissue Concentration Data (17 kB)
13-Week with Perinatal Exposure Immunotoxicity Evaluation (I11054B) of Sulfolane (126-33-0) in Male & Female Harlan Sprague Dawley Rats Exposed via Dosing in Water
Study Tables
- I01 - Animal Removal Summary (42 kB)
- I02 - Animal Removals (2 mB)
- I03 - Growth Curve (654 kB)
- I03C - Growth Curve (717 kB)
- I04 - Mean Body Weight Summary (158 kB)
- I04G - Mean Body Weight Gain (127 kB)
- I05 - Clinical Observations Summary (87 kB)
- I06 - Mean Feed Consumption (161 kB)
- I07 - Mean Water Consumption (171 kB)
- I08 - Mean Test Compound Consumption (118 kB)
- M03 - Peripheral Blood Leukocyte Cell Differential (96 kB)
- M04 - Hematology (91 kB)
- M06 - Spleen Immunophenotyping (131 kB)
- M07 - TDAR SRBC Spleen AFC (65 kB)
- M08 - Serum IgM Antibody Titers to T - Dependent Antigen Sheep Erythrocytes (40 kB)
- M09 - Serum Antibody Concentrations for the T - Dependent Keyhole Lipet Hemocyanin (KLH) (47 kB)
- M11 - Spleen Cell Proliferative Response to Anti - CD3 Stimulation (39 kB)
- M12 - Cytotoxic T Cell Activity (51 kB)
- M15 - Natural Killer Cell Activity (50 kB)
- M19 - TDAR SRBC ELISpot (44 kB)
- PA06 - Organ Weights Summary (97 kB)
- PA46 - Summary of Gross Pathology (643 kB)
Individual Animal Data
- Individual Animal Anti - SRBC IgM ELISpot Data (12 kB)
- Individual Animal Anti - SRBC Serum IgM Antibody Response Data (10 kB)
- Individual Animal Body Weight Data (181 kB)
- Individual Animal Clinical Observations Data (1 mB)
- Individual Animal Consumption Data (421 kB)
- Individual Animal Cytotoxic T Cell Activity Data (24 kB)
- Individual Animal Gross Pathology Data (117 kB)
- Individual Animal Hematology Data (25 kB)
- Individual Animal KLH TDAR Data (15 kB)
- Individual Animal Natural Killer Cell Activity Data (24 kB)
- Individual Animal Organ Weight Data (14 kB)
- Individual Animal Removal Reasons Data (27 kB)
- Individual Animal Spleen Anti - CD3 Proliferation Data (15 kB)
- Individual Animal Spleen Antibody Forming Cell Response Data (12 kB)
- Individual Animal Spleen Immunophenotyping Data (21 kB)
4-Week Evaluation of the Toxicity (C11054) of Sulfolane (126-33-0) in B6C3F1/N Mice Exposed via Gavage
Study Tables
- I01 - Animal Removal Summary (52 kB)
- I02 - Animal Removals (692 kB)
- I03 - Growth Curve (690 kB)
- I04 - Mean Body Weights and Survival (187 kB)
- I04G - Mean Body Weight Gain (70 kB)
- I05 - Clinical Observations Summary (46 kB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (406 kB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (420 kB)
- PA06 - Organ Weights Summary (149 kB)
- PA10 - Statistical Analysis of Non-Neoplastic Lesions (313 kB)
- PA14 - Individual Animal Pathology Data (3 mB)
- PA18 - Non-Neoplastic Lesion Summary with Severity Grade (407 kB)
- PA43 - Hematology Summary (297 kB)
- PA46 - Summary of Gross Pathology (464 kB)
- PA48 - Summary of Tissue Concentration (57 kB)
- Rectal Temperature Summary (38 kB)
Individual Animal Data
- Individual Animal Body Weight Data (86 kB)
- Individual Animal Clinical Observations Data (73 kB)
- Individual Animal Gross Pathology Data (306 kB)
- Individual Animal Hematology Data (26 kB)
- Individual Animal Histo Pathology Data (185 kB)
- Individual Animal Organ Weight Data (24 kB)
- Individual Animal Removal Reasons (15 kB)
- Individual Animal Temperature Data (19 kB)
- Individual Animal Tissue Concentration Data (13 kB)
4-Week Evaluation of the Toxicity (C11054) of Sulfolane (126-33-0) in Hartley Guinea Pigs Exposed via Gavage
Study Tables
- I01 - Animal Removal Summary (55 kB)
- I02 - Animal Removals (624 kB)
- I03 - Growth Curve (654 kB)
- I04 - Mean Body Weights and Survival (204 kB)
- I04G - Mean Body Weight Gain (70 kB)
- I05 - Clinical Observations Summary (51 kB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (490 kB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (416 kB)
- PA06 - Organ Weights Summary (149 kB)
- PA10 - Statistical Analysis of Non-Neoplastic Lesions (436 kB)
- PA14 - Individual Animal Pathology Data (4 mB)
- PA18 - Non-Neoplastic Lesion Summary with Severity Grade (491 kB)
- PA41 - Clinical Chemistry Summary (216 kB)
- PA43 - Hematology Summary (297 kB)
- PA46 - Summary of Gross Pathology (501 kB)
- PA48 - Summary of Tissue Concentration (57 kB)
- Rectal Temperature Summary (37 kB)
Individual Animal Data
- Individual Animal Body Weight Data (93 kB)
- Individual Animal Clinical Chemistry Data (23 kB)
- Individual Animal Clinical Observations Data (66 kB)
- Individual Animal Gross Pathology Data (402 kB)
- Individual Animal Hematology Data (287 kB)
- Individual Animal Histo Pathology Data (214 kB)
- Individual Animal Organ Weight Data (29 kB)
- Individual Animal Removal Reasons (15 kB)
- Individual Animal Temperature Data (15 kB)
- Individual Animal Tissue Concentration Data (17 kB)
3-Month Immunotoxicity Evaluation (I11054) of Sulfolane (126-33-0) in Female B6C3F1/N Mice Exposed via Oral Gavage
Study Tables
- I01 - Animal Removal Summary (33 kB)
- I02 - Animal Removals (933 kB)
- I03 - Growth Curve (64 kB)
- I04 - Mean Body Weight Summary (133 kB)
- I04G - Mean Body Weight Gain (120 kB)
- I05 - Clinical Observations Summary (157 kB)
- M03 - Peripheral Blood Leukocyte Cell Differential (64 kB)
- M04 - Hematology (59 kB)
- M06 - Spleen Immunophenotyping (84 kB)
- M07 - TDAR SRBC Spleen AFC (44 kB)
- M08 - Serum IgM Antibody Titers to T - Dependent Antigen Sheep Erythrocytes (32 kB)
- M09 - Serum Antibody Concentrations for the T - Dependent Keyhole Lipet Hemocyanin (KLH) (37 kB)
- M11 - Spleen Cell Proliferative Response to Anti-CD3 Stimulation (31 kB)
- M15 - Natural Killer Cell Activity (38 kB)
- M19 - TDAR SRBC ELISpot (34 kB)
- PA06 - Organ Weights Summary (63 kB)
- PA46 - Summary of Gross Pathology (176 kB)
Individual Animal Data
- Individual Animal Anti - SRBC IgM ELISpot Data (7 kB)
- Individual Animal Anti - SRBC Serum IgM Antibody Response Data (6 kB)
- Individual Animal Body Weight Data (122 kB)
- Individual Animal Clinical Observations Data (789 kB)
- Individual Animal Gross Pathology Data (50 kB)
- Individual Animal Hematology Data (13 kB)
- Individual Animal KLH TDAR Data (9 kB)
- Individual Animal Natural Killer Cell Activity Data (12 kB)
- Individual Animal Organ Weight Data (8 kB)
- Individual Animal Removal Reasons Data (12 kB)
- Individual Animal Spleen Anti - CD3 Proliferation Data (9 kB)
- Individual Animal Spleen Antibody Forming Cell Response Data (8 kB)
- Individual Animal Spleen Immunophenotyping Data (12 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054B in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054C in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054D in B6C3F1 Mice
Summary and Individual Animal Data
Other NTP Studies
Toxicokinetic Evaluation (K11054C) of Sulfolane (DTXSID3027037) in Rat and Mouse
Data
- Annotated Group Parameters (27 kB)
- Annotated Individual Animal Data (180 kB)
- Summary Data - Mice (172 kB)
- Summary Data - Rats (134 kB)