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Testing Status of Sulfolane 11054

 

CASRN: 126-33-0

Formula: C4-H8-O2-S

Synonyms/Common Names

  • Sulphoxaline

Short-Term Toxicity

  • 28 days (Gavage)  (C11054)  Report in Preparation 
    • Citation: Shipkowski KA, Cora MC, Cesta MF, Robinson VG, Waidyanatha S, Witt KL, Vallant MK, Fallacara DM, Hejtmancik MR, Masten SA, Cooper SD, Fernando RA, Blystone CR. Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage. Toxicol Rep. 2021 Feb 6;8:581-591. doi: https://doi.org/10.1016/j.toxrep.2021.02.004.
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N; Guinea Pigs: Hartley
    • Dose: R, M, GP: 0, 1, 10, 30, 100, 300, or 800 mg/kg 10/sex/species/dose; 20/sex in control group for GP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C11054B)  Data in Review 
    • Rat Core
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats and mice: 0, 30, 100, 300, or 1000 ppm in tap water; 50/sex/species/group.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Gavage; Intravenous)  (K11054)  Completed 
    • Citation: Waidyanatha S, Black SR, Blystone CR, Patel PR, Watson SL, Snyder RW, Fennell TR. Disposition and metabolism of sulfolane in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans. Xenobiotica. 2020 Apr;50(4):442-453. doi: https://doi.org/10.1080/00498254.2019.1630786.Epub 2019 Jul 5.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 30 mg/kg. 30, 100 or 300 mg/kg. 30, 100 or 300 mg/kg [R,M].
  • Preliminary Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K11054B)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 10 and 100 mg/kgPTKS. 10 mg/kgPTKS.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K11054C)  Completed 
    • Citation: Waidyanatha S, Black SR, Fennell TR, Watson SL, Patel PR, Cooper SD, Blake J, Robinson VG, Fernando RA, Blystone CR. Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison. Toxicol Appl Pharmacol. 2019 Sep 15;379:114690. doi: https://doi.org/10.1016/j.taap.2019.114690. Epub 2019 Jul 22.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 10 mg/kg [R,M]. 10, 30 and 100 mg/kg [R,M].

Genetic Toxicology

  • Micronucleus  (G11054)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G11054B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus (Dosed-Water)  (G11054C)  Completed 
    • Female
    • Rats: Harlan Sprague-Dawley
  • Micronucleus (Dosed-Water)  (G11054D)  Completed 
    • Female
    • Mice: B6C3F1

Organ Systems Toxicity

  • 13 weeks Immunotoxicity (Gavage)  (I11054)  Data in Review 
    • Citation: Watson ATD, Johnson VJ, Luster MI, Burleson GR, Fallacara DM, Sparrow BR, Cesta MF, Cora MC, Shockley KR, Stout MD, Blystone CR, Germolec DR. Immunotoxicity studies of sulfolane following developmental exposure in Hsd:Sprague Dawley SD rats and adult exposure in B6C3F1/N mice. J Immunotoxicol. 2021 Dec;18(1):1-12. doi: https://doi.org/10.1080/1547691x.2020.1869355.
    • Female Mice: B6C3F1/N
    • Dose: 0, 1, 10, 30, 100, or 300 mg/kg.
  • 13 weeks Immunotoxicity (Gavage)  (I11054B)  Data in Review 
    • Citation: Watson ATD, Johnson VJ, Luster MI, Burleson GR, Fallacara DM, Sparrow BR, Cesta MF, Cora MC, Shockley KR, Stout MD, Blystone CR, Germolec DR. Immunotoxicity studies of sulfolane following developmental exposure in Hsd:Sprague Dawley SD rats and adult exposure in B6C3F1/N mice. J Immunotoxicol. 2021 Dec;18(1):1-12. doi: https://doi.org/10.1080/1547691x.2020.1869355.
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 30, 100, 300, or 1000 mg/L.