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Sulfolane (126-33-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3027037


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Sulfolane (126-33-0).
Micronucleus - Rats
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Sulfolane (126-33-0).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative

Citation Information


NTP. Sulfolane (126-33-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1

1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.

DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0000-0000-0

Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

Genetox data was added on August 7, 2020
Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison Suramya Waidyanatha, Sherry R. Black, Timothy R. Fennell, Scott L. Watson, Purvi R.Patel, Stephen D. Cooper, James Blake, Veronica Godfrey Robinson, Reshan A.Fernando, Chad R. Blystone DOI: https://doi.org/10.1016/j.taap.2019.114690
Immunotoxicity Studies of Sulfolane Following Developmental Exposure in Hsd:Sprague Dawley SD Rats and Adult Exposure in B6C3F1/N Mice. K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1

1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2Battelle Memorial Institute, Columbus, OH, USA.
3RTI International, Research Triangle Park, NC, USA.

Note: The PA46 was updated on September 14, 2021 for updates to stats for calculation of % animals with a finding.

Note: M09 was updated for number of spleen cells on September 1, 2021. The new tables contain a correction to a typographical error in the units for the Ig concentrations.

Note: M07 was updated for number of spleen cells on July 22, 2021. The I07 was updated on August 12, 2021 to reflect updated footnotes. The I04G was also updated on August 22, 2021 to reflect updated statistical analysis.

DOI: https://doi.org/10.22427/NTP-DATA-002-03276-0016-0000-7

Study Data


Toxicity and Carcinogenicity Studies


4-Week Evaluation of the Toxicity (C11054) of Sulfolane (126-33-0) in Harlan Sprague Dawley Rats Exposed via Gavage
13-Week with Perinatal Exposure Immunotoxicity Evaluation (I11054B) of Sulfolane (126-33-0) in Male & Female Harlan Sprague Dawley Rats Exposed via Dosing in Water
Study Tables
Individual Animal Data
4-Week Evaluation of the Toxicity (C11054) of Sulfolane (126-33-0) in B6C3F1/N Mice Exposed via Gavage
4-Week Evaluation of the Toxicity (C11054) of Sulfolane (126-33-0) in Hartley Guinea Pigs Exposed via Gavage
3-Month Immunotoxicity Evaluation (I11054) of Sulfolane (126-33-0) in Female B6C3F1/N Mice Exposed via Oral Gavage
Study Tables
Individual Animal Data

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054 in B6C3F1 Mice
Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054B in Harlan Sprague-Dawley Rats
Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054C in Harlan Sprague-Dawley Rats
Genetic Toxicity Evaluation of Sulfolane (126-33-0) in Micronucleus Study G11054D in B6C3F1 Mice