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Testing Status of Dibenz(a,h)anthracene 11110-H

 

CASRN: 53-70-3

Formula: C22-H14

Synonyms/Common Names

  • 1,2:5,6-Dibenzanthracene

Genetic Toxicology

  • Salmonella  (381505)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (I11110)  Data in Review 
    • Citation: Hsieh JH, Sedykh A, Mutlu E, Germolec DR, Auerbach SS, Rider CV. Harnessing In Silico, In Vitro, and In Vivo Data to Understand the Toxicity Landscape of Polycyclic Aromatic Compounds (PACs). Chem Res Toxicol. 2021 Feb 15;34(2):268-285. https://doi.org/10.1021/acs.chemrestox.0c00213. Epub 2020 Oct 16.
    • Female Mice: B6C3F1
    • Dose: 0, 0.07, 0.2, 0.6, 2, 6, 17, and 50 mg/kg.
  • 28 days Immunotoxicity (Subcutaneous Injection)  (IMM20506)  Completed 
    • Immunosuppression Range Finding
    • Female Mice: B6C3F1
    • Dose: 0, 25, 79.3, 250, 793, or 2500 ug/kg.
  • 8 GD - PND 42 Immunotoxicity (Subcutaneous Injection)  (IMM20507)  Completed 
    • Developmental toxicity
    • Female Mice: B6C3F1
    • Dose: 0, 25, 79.3, 250, 793, or 2500 ug/kg.
  • 28 days Immunotoxicity (Subcutaneous Injection)  (IMM20607)  Completed 
    • Immunosuppression - Full Protocol
    • Female Mice: B6C3F1
    • Dose: 0, 250, 793, or 2500 ug/kg.