Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Melphalan 11171-J

 

CASRN: 148-82-3

Formula: C13-H18-Cl2-N2-O2

Synonyms/Common Names

  • 4-(Bis(2-chloroethyl)amino)-DL-phenylalanine

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04853)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04853)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04853)  Completed 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: R: 0, .7, 1.4, M: 0, .35, .70 MG/KG/25 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (141321)  Completed 
    • Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (283792)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (141321)  Completed 
    • Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A19873)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Male Weakly Positive 
    • Female Positive 
  • Micronucleus  (A52832)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Male Positive 
    • Female Positive 
  • Micronucleus  (A84411)  Completed 
    • Mice: FVB/N
    • Male Positive 
    • Female Positive 
  • Micronucleus  (A93719)  Completed 
    • Mice: FVB/N
    • Male Positive 
    • Female Positive 
  • Salmonella  (331518)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Sister Chromatid Exchanges  (141321)  Completed 
    • Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 

Organ Systems Toxicity

  • Dominant Lethal (Male)  (DLM96003)  Completed 
    • Citation: Generoso, WM, Witt, KL, Cain, KT, Hughes, L, Cacheiro, NLA, Lockhart, A-MC, Shelby, MD. Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutat. Res. 345: 167-180. (1995)
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Heritable Translocation Test  (HTT96002)  Completed 
    • Citation: Generoso, WM, Witt, KL, Cain, KT, Hughes, L, Cacheiro, NLA, Lockhart, A-MC, Shelby, MD. Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutat. Res. 345: 167-180. (1995)
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Morphological Specific Locus  (MSLM67)  Completed 
    • Citation: Russell, L.B., Hunsicker, P.R., and Shelby, M.D. Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids. Mutation Res. 282: 151-158 (1992).
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98021)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive