Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Nickel (II) oxide 11198-D


CASRN: 1313-99-1

Formula: Ni-O

Synonyms/Common Names

  • Nickel monoxide [Nickel and nickel compounds]

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C00862)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1.2, 2.5, 5, 10, OR 30 MG/M3; 5/GROUP.
  • 13 weeks (Inhalation)  (C00862)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.6, 1.2, 2.5, 5, OR 10 MG/M3; 10/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C00862)  Completed 
    • TR-451 (NIH Number: 96-3367)  (Peer Review Approval 11/29/1994A )
      Toxicology and Carcinogenesis Studies of Nickel Oxide in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0, .62, 1.25, OR 2.5 M: 0, 1.25, 2.5, OR 5.0 MG/M3; 50/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (K00862)  Completed 
    • Rats: Fischer 344

Genetic Toxicology

  • Micronucleus  (A32705)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A66352)  Completed 
    •  Negative