Testing Status of Nickel (II) oxide 11198-D

CASRN: 1313-99-1

Formula: Ni-O

Synonyms/Common Names

• Nickel monoxide [Nickel and nickel compounds]

Short-Term Toxicity

• 2 weeks (Inhalation)  (C00862)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 1.2, 2.5, 5, 10, OR 30 MG/M3; 5/GROUP.
• 13 weeks (Inhalation)  (C00862)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.6, 1.2, 2.5, 5, OR 10 MG/M3; 10/GROUP.

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C00862)  Completed 
  • TR-451 (NIH Number: 96-3367)  (Peer Review Approval 11/29/1994A )
    Toxicology and Carcinogenesis Studies of Nickel Oxide in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Some Evidence 
    • Female Rats Some Evidence 
    • Male Mice No Evidence 
    • Female Mice Equivocal Evidence 
  • Dose: R: 0, .62, 1.25, OR 2.5 M: 0, 1.25, 2.5, OR 5.0 MG/M3; 50/GROUP.

Special Studies

• Absorption Disposition Metabolism Elimination (Inhalation)  (K00862)  Completed 
  • Rats: Fischer 344

Genetic Toxicology

• Micronucleus  (A32705)  Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A66352)  Completed 
  •  Negative