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Testing Status of Nickel subsulfide 11234-V

 

CASRN: 12035-72-2

Formula: Ni3-S2

Synonyms/Common Names

  • Nickel sulfide

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C61654)  Completed 
    •   (Peer Review Approval 11/29/1994A ) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.6, 1.2, 2.5, 5, OR 10 MG/MG; 5/GROUP.
  • 13 weeks (Inhalation)  (C61654)  Completed 
    • Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, .15, OR 2.5 MG/M3; 10/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C61654)  Completed 
    •   (Peer Review Approval 11/29/1994A ) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
    • TR-453 (NIH Number: 96-3369)  (Peer Review Approval 11/29/1994A )
      Toxicology and Carcinogenesis Studies of Nickel Subsulfide in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 0.075, OR 0.15 M: 0, 0.6, OR 1.2 MG/M3; 50/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (K61654)  Completed 
    • Rats: F344/N

Genetic Toxicology

  • Micronucleus  (A50848)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (498230)  Completed 
    •  Equivocal