Hexabromocyclododecane (25637-99-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8025383

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Hexabromocyclododecane (25637-99-4).
Bacterial Mutagenicity
View Negative

Citation Information

NTP. Hexabromocyclododecane (25637-99-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.

Szabo DT, Pathmasiri W, Sumner S, Birnbaum LS. Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture. Environmental Health Perspectives. (2017) DOI: https://doi.org/10.1289/ehp242. PMID: 27814246

Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: 10.1016/j.dib.2020.106136. eCollection 2020 Oct. PMID: 32904430

Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738

Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick

Toxicology Letters (2020) DOI: https://doi.org/10.1016/j.toxlet.2020.07.016 PMID: 32679240

GEO: GSE153366

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

5-Day Evaluation of the Toxicity (C11297-01) of the Toxicity of 1,3,5,7,9,11-Hexabromocyclododecane (25637-99-4) in Sprague Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (29 kB)
I02 - Animal Removals (138 kB)
I03 - Growth Curve (317 kB)
I03C - Growth Curve (311 kB)
I04 - Mean Body Weight Summary (74 kB)
I04G - Mean Body Weight Gain (45 kB)
I05 - Clinical Observations Summary (32 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (128 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (105 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (129 kB)
PA06 - Organ Weights Summary (87 kB)
PA14 - Individual Animal Pathology Data (321 kB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (105 kB)
PA41 - Clinical Chemistry Summary (146 kB)
PA43 - Hematology Summary (153 kB)
PA46 - Summary of Gross Pathology (226 kB)
PA49 - Summary of Cytochrome Activity (52 kB)
R07 - Hormone Summary (41 kB)

Individual Animal Data

Individual Animal Body Weight Data (11 kB)
Individual Animal Clinical Chemistry Data (9 kB)
Individual Animal Clinical Observations Data (11 kB)
Individual Animal Cytochrome Activity Data (8 kB)
Individual Animal Gross Pathology Data (61 kB)
Individual Animal Hematology Data (10 kB)
Individual Animal Histopathology Data (6 kB)
Individual Animal Hormone Data (6 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (5 kB)