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Testing Status of 1,3,5,7,9,11-Hexabromocyclododecane 11297-E

 

CASRN: 25637-99-4

Formula: C12-H18-Br6

Synonyms/Common Names

  • Cyclododecane, hexabromo-
  • Flame Retardant 2
  • 1,3,5,7,9,11-HBCD

Short-Term Toxicity

  • 5 days (Gavage)  (C11297)  Report in Preparation 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

Genetic Toxicology

  • 4 hours Comet Assay (in-vitro)  (G11297)  On Test 
    • Human (Cell Lines)
  • 24 hours Comet Assay (in-vitro)  (G11297B)  On Test 
    • Human (Cell Lines)
  • Salmonella  (045544)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T11297)  Report in Preparation 
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.