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Testing Status of 5-Amino-o-cresol 11462-W

 

CASRN: 2835-95-2

Formula: C7-H9-N-O

Synonyms/Common Names

  • 4-Amino-2-hydroxy-1-methylbenzene
  • 4-Amino-2-hydroxytoluene
  • 3-Amino-6-methylphenol
  • 3-Hydroxy-4-methylaniline

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C20214)  Completed 
    • TOX-89 (NIH Number: 16-5939)  (Tox Peer Review 12/00/2013A )
      Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R: 0, 2, 4, 8, 16, or 32 mg/kg; 20/sex/dose M: 0, 8, 16, 32, 64, or 128 mg/kg; 10/sex/dose.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Gavage)  (S0852)  Completed 
    • Citation: Hedtke B, Gao Z, Chen L-J, Weber WM, Dix KJ. Metabolism and disposition of [14C]5-amino-o-cresol in female F344 rats and B6C3F1 mice. Xenobiotica. Feb 2008; 38(2): 171-184Pubmed Abstract
    • Female Rats: F344/N; Female Mice: B6C3F1
    • Dose: (all routes) 2, 20, 3.5, 35, 350 mg/kg [R,M].

Genetic Toxicology

  • Micronucleus  (A04294)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A62651)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (F62651)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (576026)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 

Organ Systems Toxicity

  • 3 to 7 days Immunotoxicity (Topical Application)  (IMM20302)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.625, 1.25, 2.5, 5, OR 10%.