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Testing Status of 1,3-Dichloro-2-propanol 11538-C

 

CASRN: 96-23-1

Formula: C3-H6-Cl2-O

Synonyms/Common Names

  • Dichlorohydrin
  • 1,3-Dichloro-2-hydroxypropane
  • 1,3-Dichloropropanol

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (K11538)  Completed 
    • Citation: Waidyanatha S, Gaudette NF, Hong Y, Fennell TR. Formation of epichlorohydrin, a known rodent carcinogen, following oral administration of 1,3-dichloro-2-propanol in rats. Chem Res Toxicol. 2014 Oct 20;27(10):1787-95. doi: 10.1021/tx500239q. Epub 2014 Oct 9.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1
    • Dose: 20 mg/kg. 50 mg/kg.

Genetic Toxicology

  • Comet Assay  (G11538B)  Completed 
    • Mice
  • Micronucleus  (G11538)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (843274)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive