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Testing Status of Phenolic Benzotriazoles (Bumetrizole) 12011

 

CASRN: 3896-11-5

Formula: C17-H18-Cl-N3-O

Synonyms/Common Names

  • 2-(2-Hydroxy-3-tert-butyl-5-methylphenyl)-5-chloro-2H-benzotriazole
  • PBZT

Secondary:

  • BENZOTRIAZOLES - Phenolic Benzotriazoles

Short-Term Toxicity

  • 14 days (Gavage)  (C12011)  Data in Review 
    • Benzotriazole Class
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 30, 100, 300, or 1000 mg/kg in 0.5% aqueous methylcellulose by gavage.

Special Studies

  • Single day Toxicokinetic Study (Gavage; Intravenous)  (K12011)  Data in Review 
    • Citation: Waidyanatha S, Mutlu E, Gibbs S, Pierfelice J, Smith JP, Burback B, Blystone CT. Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats. Xenobiotica. 2021 Jul;51(7):831-841. doi: https://doi.org/10.1080/00498254.2021.1927239. Epub 2021 May 24.Pubmed Abstract
    • Male Rats: Harlan Sprague-Dawley
    • Dose: 30 mg/kg. 30, 300 mg/kg.

Genetic Toxicology

  • Micronucleus (Gavage)  (G12011)  Completed 
    • Rats: Harlan Sprague-Dawley