Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Phenolic Benzotriazoles (2-(5-Chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol) 12013

 

CASRN: 3864-99-1

Formula: C20-H24-Cl-N3-O

Synonyms/Common Names

  • ditBu-CIBZT
  • 2,4-Di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol
  • PBZT

Secondary:

  • BENZOTRIAZOLES - Phenolic Benzotriazoles

Short-Term Toxicity

  • 14 days (Gavage)  (C12013)  Data in Review 
    • Benzotriazole Class
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 30, 100, 300, or 1000 mg/kg in 0.5% aqueous methylcellulose by gavage.

Special Studies

  • Single day Toxicokinetic Study (Gavage; Intravenous)  (K12013)  Completed 
    • Citation: Waidyanatha S, Mutlu E, Gibbs S, Pierfelice J, Smith JP, Burback B, Blystone CT. Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats. Xenobiotica. 2021 Jul;51(7):831-841. doi: https://doi.org/10.1080/00498254.2021.1927239. Epub 2021 May 24.Pubmed Abstract
    • Male Rats: Harlan Sprague-Dawley
    • Dose: 30 mg/kg. 30, 300 mg/kg.

Genetic Toxicology

  • Micronucleus (Gavage)  (G12013)  Completed 
    • Rats: Harlan Sprague-Dawley