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Testing Status of Vinpocetine 12103

 

CASRN: 42971-09-5

Formula: C22-H26-N2-O2

Synonyms/Common Names

  • Apovincaminic acid ethyl ester
  • Bravinton
  • Cavinton
  • Ceractin
  • Cis-apovincaminic acid ethyl ester
  • Ethyl (+)-apovincaminate
  • Ethyl (+)-cis-apovincaminate
  • Ethyl (3α,16α)-eburnamenine-14-carboxylate
  • Ethyl apovincamin-22-oate
  • Intelectol
  • RGH-4405
  • TCV-3B
  • Vinporal

Special Studies

  • Toxicokinetic Study (Gavage)  (K12103)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 5 and 20 mg/kg.

Genetic Toxicology

  • Comet Assay  (G12103D)  Completed 
    • Definitive
    • Mice: B6C3F1
  • Micronucleus (Gavage)  (G12103B)  Completed 
    • Ranger-finder female
    • Mice: B6C3F1
  • 3 days Micronucleus (Gavage)  (G12103C)  Completed 
    • Definitive
    • Mice: B6C3F1
  • Micronucleus (Gavage)  (G12103E)  Completed 
    • Human (Cell Lines)
  • Salmonella  (G12103)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to GD 20 Conventional Teratology (Gavage)  (R12103B)  Report in Preparation 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 5, 20 or 60 mg/kg/day; 25/rats per group.
  • GD 7 to GD 28 Teratology Pilot Studies (Gavage)  (R12103D)  Report in Preparation 
    • Investigative Study
    • Rabbit: New Zealand White
    • Dose: 0, 25, 75, 150, or 300 mg/kg/group; 8 rabbits/group.
  • GD 6 to GD 20 Teratology Pilot Studies (Gavage)  (R12103)  Report in Preparation 
    • Teratology Dose Range Finder (DRF)
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 20, 40, 80, 160, or 320 mg/kg; 10 rats/group.