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Testing Status of 2-ethylhexyl-2,3,4,5-tetrabromobenzoate 13063

 

CASRN: 183658-27-7

Formula: C15H18Br4O2

Synonyms/Common Names

  • Benzoic acid, 2,3,4,5-tetrabromo-, 2-ethylhexyl ester
  • Flame Retardant 2
  • TBB

Short-Term Toxicity

  • 5 days (Gavage)  (C13063)  Report in Preparation 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

Genetic Toxicology

  • 4 hours Comet Assay (in-vitro)  (G13063B)  On Test 
    • Human (Cell Lines)
  • 24 hours Comet Assay (in-vitro)  (G13063C)  On Test 
    • Human (Cell Lines)
  • 48 hours Salmonella (in-vitro)  (G13063)  Completed 

    Toxicogenomics

    • 5 days Microarray Analysis (Gavage)  (T13063)  Report in Preparation 
      • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
      • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
      • Rats: Hsd:Sprague Dawley SD
      • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.