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Testing Status of Tricombination FTC:TDF:EFV (1:1.5:3) 13067



Formula: C19H30N5O10P.C14H9ClF3NO2.C8H10FN3O3S.C4H4O4

Synonyms/Common Names

  • Tri-Combo Therapy (TDF/EFV/FTC)
  • Tri-combo therapy (TDF/EFV/FTC) (AIDS)


  • 154598-52-4 - Efavirenz (EFV)
  • 143491-57-0 - Emtricitabine (FTC)
  • 202138-50-9 - Tenofovir Disoproxil Fumarate (TDF)

Modified One-Generation

  • F0 Generation (Gavage)  (MOG13067)  On Test 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • 13-Week Subchronic (Gavage)  (MOG13067B)  On Test 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • Maternal Transfer (Gavage)  (MOG13067C)  On Test 
    • Biological Sampling for Subchronic Mouse Study MOG13067B
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]

Special Studies

  • GD 5 - GD 15 Preliminary Toxicokinetic Study (Gavage)  (K13067)  Completed 
    • Mice
    • Dose: 50:75:150 MG/KG.

Organ Systems Toxicity

  • GD 5-15 Maternal Transfer (Gavage)  (R13067D)  Report in Preparation 
    • Mice: CD-1
    • Dose: Emtricitabine 50 mg/kg/day, Tenofovir 75 mg/kg/day, and Efavirenz 150 mg/kg/day.
  • GD 5 - GD 18 Teratology Pilot Studies (Gavage)  (R13067)  Report in Preparation 
    • Dose Range-Finding
    • Mice: CD-1