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Testing Status of Cresols 1319773

 

CASRN: 1319-77-3

Formula: C7-H8-O

Synonyms/Common Names

  • Cresols (Mixed Isomers Of ortho, meta, para)
  • Cryslol
  • Hydroxytoluene
  • Methylphenol (9CI)
  • Tricresol

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C62260)  Completed 
    • TOX-09 (NIH Number: 92-3128)  (Peer Review Approval 11/20/1990A )
      Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C62260)  Completed 
    • TOX-09 (NIH Number: 92-3128)
      Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, .03, .1, .3, 1.0, 3.0% IN DIET.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C62260B)  Completed 
    • TR-550 (NIH Number: 08-5891)  (Peer Review Approval 05/17/2007A )
      Toxicology and Carcinogenesis Studies of Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 1500, 5000, or 15, 000 PPM and M: 0, 1000, 3000, or 10, 000 PPM; 50/species/dose.

Genetic Toxicology

  • Micronucleus  (A73499)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (990849)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (A67379)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB90003)  Completed 
    • Mice: Swiss
    • Dose: 0, 0.25, 0.5, 1.0, 2.0, 3.0%; 0, 0.25, 1.0, 1.5%; 0, 1.5%; 0, 0.25, 1.0, 1.5%.