Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Crude MCHM 14013

 

CASRN: CRUDEMCHM

Secondary:

  • 94-60-0 - Dimethyl 1,4-cyclohexanedicarboxylate
  • 105-08-8 - 1,4-Cyclohexanedimethanol
  • 67-56-1 - Methanol
  • 98955-27-2 - 4-Methoxymethylcyclohexylmethanol
  • 51181-40-9 - Methyl 4-methylcyclohexanecarboxylate
  • 34885-03-5 - 4-Methylcyclohexanemethanol (MCHM)

Short-Term Toxicity

  • 5 days (Gavage)  (C14013)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: MR: 0, 0.1, 1, 10, 100, 300, or 500 mg/kg; 8 rats in 0 mg/kg group, 6 rats in each treated group.

Special Studies

  • C. elegans  (W14013)  Completed 
    • C. elegans: N2
    • Dose: Feeding: 200, 100, 75, 50uM Repro: 200, 100, 75, 50uM Growth: 200, 100, 75, 50uM.
  • 5 days Zebrafish (Dosed-Water)  (Z14013)  Completed 
    • Zebrafish
    • Fish: Zebra (Danio rerio)

Genetic Toxicology

  • Micronucleus  (G14013)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
  • Salmonella  (G14013B)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 7 days Immunotoxicity (Topical Application)  (I14013)  Completed 
    • Citation: National Toxicology Program (NTP). 2020. NTP immunotoxicity technical report on the dermal hypersensitivity and irritancy studies of 4-methylcyclohexanemethanol (CASRN 34885-03-5) and crude 4-methylcyclohexanemethanol administered topically to female BALB/c mice. Research Triangle Park, NC: National Toxicology Program. Immunotoxicity Report 01.
    • Female Mice: BALB/c
    • Dose: 1, 2, 5, 20, 40, or 100/80%.
  • 7 days Immunotoxicity (Topical Application)  (I14013B)  Completed 
    • Citation: National Toxicology Program (NTP). 2020. NTP immunotoxicity technical report on the dermal hypersensitivity and irritancy studies of 4-methylcyclohexanemethanol (CASRN 34885-03-5) and crude 4-methylcyclohexanemethanol administered topically to female BALB/c mice. Research Triangle Park, NC: National Toxicology Program. Immunotoxicity Report 01.
    • Female Mice: BALB/c
    • Dose: 1, 5, 25, 50, or 75%.

Toxicogenomics

  • Microarray Analysis (Gavage)  (T14013)  Completed 
    • Short Term Toxicogenomic Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: 0.1, 1, 10, 100, 300, or 500 mg/kg; 6 rats/dose group.