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Testing Status of Hexachlorocyclopentadienyl-dibromocyclooctane 15003

 

CASRN: 51936-55-1

Formula: C13H12Br2Cl6

Synonyms/Common Names

  • Flame Retardant 2
  • HCDBCO

Short-Term Toxicity

  • 5 days (Gavage)  (C15003)  Completed 
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

Genetic Toxicology

  • 4 hours Comet Assay (in-vitro)  (G15003B)  On Test 
    • Human (Cell Lines)
  • 24 hours Comet Assay (in-vitro)  (G15003C)  On Test 
    • Human (Cell Lines)
  • 48 hours Salmonella (in-vitro)  (G15003)  Completed 

    Toxicogenomics

    • 5 days Microarray Analysis (Gavage)  (T15003)  Completed 
      • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
      • Rats: Hsd:Sprague Dawley SD
      • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.