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Testing Status of Echinacea purpurea root extract 16001

 

CASRN: 90028-20-9

Synonyms/Common Names

  • ECH
  • Echinacea purpurea
  • Echinacea purpurea extract

Modified One-Generation

  • 6 weeks Dose Range Finding (Gavage)  (MOG16001)  Data in Review 
    • Perinatal Dose Range-Finding MOG Study of Echinacea purpurea extract
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 125, 250, 500, 1000, or 2000 mg/kg/day.
  • 3 weeks Conventional Teratology (Gavage)  (MOG16001B)  On Test 
    • Rats: Harlan Sprague-Dawley
    • Dose: 100, 300, 1000 mg/kg/day by gavage.
  • 17 weeks Fertility Assessment (Gavage)  (MOG16001B)  On Test 
    • Rats: Harlan Sprague-Dawley
    • Dose: 100, 300, 1000 mg/kg/day by gavage.
  • 13 weeks Subchronic (Gavage)  (MOG16001B)  On Test 
    • Rats: Harlan Sprague-Dawley
    • Dose: 100, 300, 1000 mg/kg/day by gavage.

Genetic Toxicology

  • 28 days (dams) Micronucleus (Gavage)  (G16001)  Completed 
    • Rats: Harlan Sprague-Dawley
  • 28 days (pups) Micronucleus (Transplacental & Gavage)  (G16001B)  Completed 
    • Rats: Harlan Sprague-Dawley
  • 119 ± 2 days Micronucleus (Gavage)  (G16001C)  Completed 
    • Rats: Harlan Sprague-Dawley

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (I99067)  On Test 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 125, 250, 500, 1000, or 2000 mg/kg.