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Testing Status of Thallium (I) sulfate 16019

 

CASRN: 7446-18-6

Formula: H2-O4-S.2Tl O4-S.2Tl

Synonyms/Common Names

  • Thallium & Salts

Planned Carcinogenicity/Toxicity

  • 14 days (Gavage) Selected (C16019B)  
    • Series Dose Escalation Cardiovascular Functional Assessment Study
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.25, 0.50, 0.75, 1, 3 mg/kg.

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C16019)  Data in Review 
    • Mice: B6C3F1
    • Dose: M: 5/sex/group 0, 6.25, 12.5, 25, 50, 100 mg/L.
  • GD 6 to PND 28 (Dosed-Water)  (C16019)  Data in Review 
    • Rats: Harlan Sprague-Dawley
    • Dose: R: 0, 3.13, 6.25, 12.5, 25, 50 mg/L; Dams 12/group 3.13, 12.5, 50 mg/L; Dams 20/group 0, 6.25, 25 mg/L.
  • 90 days (Dosed-Water)  (C16019)  On Test 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: 0, 0.78, 1.56, 3.13, 6.25, or 12.5 mg/L. 0, 1.25, 2.5, 5, 10, or 20 mg/L.

Genetic Toxicology

  • 3 months Micronucleus (Dosed-Water)  (G16019)  Data in Review 
    • Rats: Harlan Sprague-Dawley
  • 3 months Micronucleus (Dosed-Water)  (G16019C)  On Test 
    • Mice: B6C3F1/N
  • 3 months Pig-a gene mutation (Dosed-Water)  (G16019B)  Data in Review 
    • Rats: Harlan Sprague-Dawley
  • 3 months Pig-a gene mutation (Dosed-Water)  (G16019D)  On Test 
    • Mice: B6C3F1/N