Testing Status of t-Butylhydroquinone 1948330

CASRN: 1948-33-0

Formula: C10-H14-O2

Synonyms/Common Names

• 1,4-Benzenediol, 2-(1,1-dimethylethyl)-
• MTBHQ

Short-Term Toxicity

• 13 weeks (Dosed-Feed)  (C62157)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.25, 0.5, 1.0, 2.0, OR 4.0% IN FEED.

Long-Term Carcinogenicity

• lifetime (Dosed-Feed)  (C62157)  Completed 
  • TR-459 (NIH Number: 97-3375)  (Peer Review Approval 06/20/1995A )
    Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats No Evidence 
    • Female Rats No Evidence 
    • Male Mice No Evidence 
    • Female Mice No Evidence 
  • Dose: R&M: 0, 0.125, 0.25, OR 0.5% IN FEED; 70 RATS, 60 MICE.

Genetic Toxicology

• Chromosome Aberrations  (A73022)  Completed 
  • Mice
  •  Negative 
• In Vitro Cytogenetics (CA/SCE)  (089956)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Micronucleus  (A34876)  Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (663851)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative 
• Salmonella  (A71156)  Completed 
  •  Equivocal 

Organ Systems Toxicity

• Immunotoxicity (Gavage)  (IMM87036)  Completed 
  • Female Mice: B6C3F1
  • Dose: 0, 25, 75, 150 MG/KG.