Testing Status of trans-Retinoic acid 302794

C. elegans (S0924) Completed
- C. elegans
- Dose: Feed: (0, 10, 16, 25, 40, 63, 100, 16-, 250, 400, 630, 1000)uM; repro: (0, 10, 16, 25, 40, 63, 100, 16-, 250, 400, 630, 1000)uM growth: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, ) uM.
Mechanisms (Gavage) (S0485) Completed
- Citation: Abbott BD, Hill LG, Birnbaum LS. Processes involved in retinoic acid production of small embryonic palatal shelves and limb defects. Teratology. 1990 Mar;41(3):299-310.Pubmed Abstract
- Female Mice: C57BL/6
- Dose: 100 MG/KG.
Mechanisms (Gavage) (S0687) Completed
- Citation: Abbott BD, Birnbaum LS. Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD. Toxicol Appl Pharmacol. 1989 Jun 15;99(2):287-301.Pubmed Abstract
- Male and Female Mice: C57BL/6

7, 8, 9 or 10 GD Conventional Teratology (Gavage) (TER86130) Completed
- Female Hamsters: LVG (SYR)
- Hamsters Maternal Inadequate
- Hamsters Fetal Inadequate
- Dose: 60 MG/KG ON GD 7; 80 MG/KG ON GD 8-10.
single Preimplantation Zygote Effects (Intraperitoneal Injection) (PZE98001) Completed
- Citation: Rutledge, JC, Shourbaji, AG, Hughes, LA, Polifka, JE, Cruz, UP, Bishop, JB, and Generoso, WM. Limb and lower-body duplications induced by retinoic acid in mice. Proc. Natl. Acad. Sci. USA 91:5436-5440 (1994).
- Female Mice: (C3H X C57BL10)F1
- Mice Female Positive
8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage) (T0108A) Completed
- Female Mice: Swiss