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Testing Status of 2,4-Toluene diisocyanate 584849

 

CASRN: 584-84-9

Formula: C9-H6-N2-O2

Synonyms/Common Names

  • 2,4-Diisocyanato-1-methylbenzene (9CI)
  • Isocyanic acid, 4-methyl-M-phenylene ester

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0208)  Completed 
    • Male Rats: Fischer 344
    • Dose: 7. 70, or 700 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (644663)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (445615)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Salmonella  (928398)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive