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Testing Status of Anthraquinone 84651

 

CASRN: 84-65-1

Formula: C14-H8-O2

Synonyms/Common Names

  • 9,10-Anthracenedione

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C88036)  Completed 
    • Rats: F344/N
    • Dose: R: 0, 469, 938 OR 3750 PPM; 20/SEX/GROUP.
  • 13 weeks (Dosed-Feed)  (C88036)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1875, 3750, 7500, 15000, OR 30000 PPM; R: 20/SEX/GROUP M: 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C88036)  Completed 
    • TR-494 (NIH Number: 05-3953)  (Peer Review Approval 12/09/2004A )
      Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 469, 938, 1875, OR 3750 PPM M: 0, 833, 2500, OR 7500 PPM.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0182)  Completed 
    • Male Rats: F344/N
    • Dose: 0.35, 3.5, 35, 350 mg/kg.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (S0558)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0 & 400 mg/kg, preliminary single administration. 2 mg/kg, preliminary single administration. 4 mg/kg, preliminary single administration. 80 & 800 mg/kg, preliminary single administration.

Genetic Toxicology

  • Micronucleus  (404278)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A47616)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Salmonella  (480416)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Salmonella  (A07496)  Completed 
    •  Negative 
  • Salmonella  (A40147)  Completed 
    •  Positive 
  • Salmonella  (A48640)  Completed 
    •  Negative 
  • Salmonella  (A54984)  Completed 
    •  Negative 
  • Salmonella  (A65343)  Completed 
    •  Negative