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Testing Status of Polyvinyl alcohol 9002895

 

CASRN: 9002-89-5

Formula: (C2-H4-O)x-

Synonyms/Common Names

  • Homopolymer ethanol (9CI)
  • Vinyl alcohol, polymers (8CI)

Short-Term Toxicity

  • 4 weeks (Intravaginal)  (C88066)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 20 UL OF 25% PVA - NO RESTRAINT, 20 UL OF 25% PVA WITH RESTRAINT; 50/GROUP.

Long-Term Carcinogenicity

  • 2 years (Intravaginal)  (C88066)  Completed 
    • TR-474 (NIH Number: 98-3964)  (Peer Review Approval 12/12/1996A )
      Toxicology and Carcinogenesis Studies of Polyvinyl Alcohol (Molecular Weight = 24,000) in Female B6C3F1 Mice (Intravaginal Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Female Mice No Evidence 
    • Dose: 25% PVA, VEHICLE, UNTREATED; 100/GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Intravaginal)  (S0695)  Completed 
    • Citation: Sanders JM, Matthews HB. Vaginal absorption of polyvinyl alcohol in Fischer 344 rats. Hum Exp Toxicol. 1990 Mar;9(2):71-7.Pubmed Abstract
    • Male Rats: F344/N; Female Rats: F344/N