Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Isophosphamide C01638


CASRN: 3778-73-2

Formula: C7-H15-Cl2-N2-O2-P

Synonyms/Common Names

  • N,3-Bis(2-chloroethyl)tetrahydro-2H,1,3,2-oxazaphospharin-2-amine,2-oxide (9CI)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01638)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01638)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: MR: 0, 2.4, 48, MM: 0, 4, 80 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01638)  Completed 
    • TR-032 (NIH Number: 77-832)  (Peer Review Approval 09/26/1977A )
      Bioassay of Isophosphamide for Possible Carcinogenicity (CASRN 3778-73-2)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0, 6, 12, M: 0, 10, 20 MG/KG/35 PER GROUP.