Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Sodium nitrite C02084

 

CASRN: 7632-00-0

Formula: H-N-O2.Na

Synonyms/Common Names

  • Diazotizing salts
  • Nitrous acid, sodium salt

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C88007)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 375 - 5000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C88007B)  Completed 
    • TR-495 (NIH Number: 01-3954)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of Sodium Nitrite (CASRN 7632-00-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R&M: 0, 0.075, 0.15, OR 0.3%; 50/SEX/DOSE.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0548)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: RATS (M & F) IV=20MG/KG, ORALLY=40 OR 80MG/KG MICE (M & F) IV=20MG/KG, ORALLY=62.5 OR 125MG/KG.

Genetic Toxicology

  • Micronucleus  (A10342)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A17282)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A52858)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (359703)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Dosed-Water)  (RACB88071)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .06, .12, .24, .36, .48%; 0, .06, .12, .24%; N/A; 0, .24%.