Testing Status of 6-Mercaptopurine C04886
CASRN: 50-44-2
Formula: C5-H4-N4-S
Synonyms/Common Names
- 1,7-Dihydro-6H-purine-6-thione (9CI)
Short-Term Toxicity
- 14-Day (Intraperitoneal Injection)
(C04886)
Completed
- Rats: Sprague Dawley; Mice: Swiss
- 13-Week (Intraperitoneal Injection)
(C04886)
Completed
- Rats: Sprague Dawley; Mice: Swiss
Long-Term Carcinogenicity
- 2-Year (Intraperitoneal Injection)
(C04886)
Completed
- (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
- Rats: Sprague Dawley; Mice: Swiss
- Dose: R: 0, 25, 50, M: 0, 15, 30 MG/KG/25 PER GROUP.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(310403)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
Organ Systems Toxicity
- Total Reproductive Capacity (Intraperitoneal Injection)
(TRC98022)
Completed
- Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
- Female Mice
- Mice Female Negative