Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Microcystin LR M000056

 

CASRN: 101043-37-2

Formula: C49-H74-N10-O12

Synonyms/Common Names

  • CN Toxin I
  • Cyanoginosin LA, 5-L-Arginine-
  • Toxin T 17

Modified One-Generation

  • GD 6 to PND 35 Dose Range Finding (Gavage)  (MOG00056)  Completed 
    • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 0, 50, 250, 500, or 1000 ug/kg/day.

Special Studies

  • Repeat (5 days) Absorption Disposition Metabolism Elimination (Gavage)  (K00056)  On Test 
    • Female Rats: Harlan Sprague-Dawley; Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 500 mg/kg.
  • Single day Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Gavage; Intravenous)  (K00056)  On Test 
    • Female Rats: Harlan Sprague-Dawley; Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 10 mg/kg. 500 mg/kg.

Genetic Toxicology

  • 21 days Micronucleus (Gavage)  (G00056)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • 21 days Micronucleus (Transplacental)  (G00056B)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • 21 days Pig-a gene mutation (Gavage)  (G00056C)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • 21 days Pig-a gene mutation (Transplacental)  (G00056D)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]