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Testing Status of Microcystin LR M000056

 

CASRN: 101043-37-2

Formula: C49-H74-N10-O12

Synonyms/Common Names

  • CN Toxin I
  • Cyanoginosin LA, 5-L-Arginine-
  • Toxin T 17

Modified One-Generation

  • GD 6 to PND 35 Dose Range Finding (Gavage)  (MOG00056)  Completed 
    • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 0, 50, 250, 500, or 1000 ug/kg/day.

Special Studies

  • Repeat (5 days) Absorption Distribution Metabolism Excretion (Gavage)  (K00056)  On Test 
    • Female Rats: Harlan Sprague-Dawley; Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 500 mg/kg.
  • Single day Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Gavage; Intravenous)  (K00056)  On Test 
    • Female Rats: Harlan Sprague-Dawley; Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 10 mg/kg. 500 mg/kg.

Genetic Toxicology

  • 21 days Micronucleus (Gavage)  (G00056)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • 21 days Micronucleus (Transplacental)  (G00056B)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • 21 days Pig-a gene mutation (Gavage)  (G00056C)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]
  • 21 days Pig-a gene mutation (Transplacental)  (G00056D)  Completed 
    • Mice: CD-1 Reg.[Crl:CD1(ICR)]